Interaction of ionic liquids with human serum albumin in the view of bioconcentration: a preliminary study

Abstract Bioaccumulation potential is critical in PBT and risk assessment of chemicals. However, for ionic liquids (ILs), this aspect remains neglected. It especially important to fill gap, because group compounds, existing data confirm their being environmentally persistent toxicity. Moreover, considering preliminary reports on the interactions ILs with lipids, it may be assumed that have a higher bioaccumulation than indicated by previous estimations built upon octanol–water partition coefficients. bioconcentration ionizable chemical compounds also strongly related plasma protein contents. Therefore, work, affinity set imidazolium cations organic anions, combination human serum albumin (HSA) was determined. The obtained results reveal both anions can bound HSA, blood proteins might play an role overall bioaccumulation. Furthermore, observed HSA binding properties towards IL depend hydrophobicity cations. provide indication cation–anion interaction affect ions HSA.